The clinical stage was T2, T3, and T4 in 13, 16, and 3 patients, respectively. We examined locally invasive bladder cancer in 32 patients (30 men, 2 women mean age at treatment 68.1 years) who underwent bladder-sparing protocols in the Department of Urology at Sumitomo Hospital between 20. We investigated the long-term results and molecular markers of outcome with selective organ preservation in invasive bladder cancer using chemoradiation therapy. (author)īladder preservation using chemoradiation therapy for locally invasive bladder cancerĪbe, Toyofumi Yoshioka, Toshiaki Sato, Mototaka Mori, Naoki Sekii, Ken-Ichiro Itatani, Hiroaki These results suggest that patients with locally invasive G2 tumor could be candiates for bladder preservation therapy and patients who underwent bladder preservation therapy should be evaluated at 10 years post- therapy. Five of them died of cancer and two patients were alive with cancer. Only 17 patients survived more than 5 years after treatment 78% of the survivors had good PS (0 or 1). Tumor grade was the most predictable prognostic factor using multivariate analysis. The prognostic factors of these patients were size and grade of tumor, presence of hydronephrosis and performance status (PS) of the patients by univariate analysis. The prognosis for the patients who underwent bladder preservation therapy was worse than that for the patients who underwent total cystectomy.
The therapeutic modalities of bladder preservation were mainly radiation or chemotherapy. The prognoses and prognostic factors of the 54 patients with locally invasive bladder cancer who underwent bladder preservation therapy at Yokohama City University Hospital between 19 were analyzed statistically. Noguchi, Sumio Takase, Kazunori Kubota, Yoshinobu Masuda, Mitsunobu Yao, Masahiro Hosaka, Masahiko International Nuclear Information System (INIS) Long-term survival of bladder preservation therapy with radiation and chemotherapy for locally invasive bladder cancer
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